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PE-22-28

Spadin analog. TREK-1 channel modulator, antidepressant research.

Route
SUBQ
Typical dose range
500 mcg to 1 mg
Frequency
daily
Half-life
4 hours
Cycle on / off (days)
14 / 14
Evidence grade
C

Reconstitution math

Open the pre-filled PE-22-28 reconstitution calculator to compute syringe units per dose.

Reported Side Effects of PE-22-28

Effects below are summarised from peer-reviewed literature or regulatory labeling where it exists. Not medical advice. Individual responses vary.

  • Transient anxiety, restlessness, or headache PubMed
  • Dry mouth and nasal dryness with intranasal forms PubMed
  • Sleep disturbance if dosed late in the day PubMed
  • Mood changes reported in a subset of users PubMed

Compare PE-22-28

How PE-22-28 stacks up against the peers most users consider.